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ApoE and ABCA1 are expressed in the central nervous system and in the periphery and measuring their expression should give a good indication of target engagement by bexarotene in both the central nervous system and the periphery.
For these reasons, it may be more useful to measure or infer miRNA activity changes instead of measuring their expression changes.
Instead, we tested this hypothesis by designing a set of new genes using new codon bias tables, measuring their expression and comparing with that predicted by the model.
To investigate this, we compared the proliferative status of DN γδ thymocytes in WT γδTCR Tg, Lck+/− γδTCR Tg, and Fyn+/− γδTCR Tg mice by measuring their expression of the Ki-67 Ag, which is a marker of actively cycling cells [34], [35].
Further, we validated these miRNAs by measuring their expression in tumors tissues and adjacent liver tissues.
Although the set of active miRNAs can often be determined experimentally (by measuring their expression levels), identifying their targets is much more challenging.
Similar(51)
To verify that these genes were also differently expressed in our cellular models, we measured their expression levels using real time polymerase chain reaction (RT-PCR).
To determine whether capn3a and capn3b were expressed normally in the def hi429 mutant, we measured their expression levels in zebrafish.
To study the role of micro-RNA (miRNA -200b and miRNA -200bn humandovulation and to measure their expression levels in ovulatory and anovulatory patients.
We identified three putative fatty-acyl-CoA reductase (fcr) genes in Mtb genome and measured their expression under the multiple-stress condition.
We reasoned that in the absence of Gfi1 the coordinated expression of key transcription factors might be disturbed and measured their expression levels in defined progenitor B cell populations by RT-PCR.
More suggestions(15)
measure their expression
measuring their progress
measuring their exposure
measuring their success
measuring their occupancy
measuring their collapse
measuring their concentration
measuring their similarity
measuring their attenuation
measuring their revenue
measuring their resistance
measuring their impact
measuring their residual
measuring their firing
measuring their value
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