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Biomarkers for measuring progression of disease would be invaluable for studying neurodegenerative disease such as Huntington's disease (HD).
As a result, the ADAS-Cog is limited in measuring progression of cognitive impairment over the course of disease progression.
Of course, these two decisions are inextricably linked; the best method for measuring progression of subjects over time will depend on the subjects who are being studied.
However, several concerns have been raised recently regarding its sensitivity in measuring progression of cognitive impairment in clinical trials [ 2– 5].
We have confirmed that measuring progression of cartilage thinning over time is possible using MRI but our data suggest that plain radiography could be comparable in terms of separating patients from controls, when considering this endpoint alone.
The proposed scoring methodology significantly improves the sensitivity of the ADAS-Cog in measuring progression of cognitive impairment in clinical trials focused in the mild-to-moderate Alzheimer's disease stage.
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A comparison between the predicted and measured progression of temperature in the GFRP bars is shown in Fig. 7.
The present study was designed to identify objective parameters to measure progression of hereditary TTR amyloidosis and determine if these parameters would show significant change within 1 year.
Here, we use GHR ubiquitination to measure progression of the GHR in the endocytosis process.
Two groups of sham operated animals were maintained on the same diet as before surgery (BBs and CCs). Figure 5 illustrates the results of Echo measured progression of LV volumes and MI expansion and functional decline in these four groups from baseline (pre-MI, 0 wks) to 10 weeks following MI induction.
We measured progression of peripheral atherosclerosis using this index.
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