The leukocyte composition was grouped for each measured cell type, and stratified for donors paired with healthy recipients (n = 39), recipients developing mild (n = 37) and severe aGVHD (n = 9).
By looking at the ratios and absolute levels of certain measured cell types and chemicals, the researchers could identify just where a mouse was along the looping path from health to sickness to recovery or death, and how likely it was to die barring further intervention.
The ratios and absolute levels of those measured cell types and substances wound up telling the researchers just where a mouse was along the looping path from health to sickness to recovery or death, and how likely it was to die barring further intervention.
If we can effectively transform those values, our method without any modifications or retraining may be able to measure cell-type-specific signals in these cross-platform experiments.
Cell-type-specific eQTLs might also be recovered by including measured cell-type abundance as a covariate in the regression model used to identify associations in tissues that are a mixture of cells [ 88], such as blood.
Montaño, C. M. et al. Measuring cell-type specific differential methylation in human brain tissue.
Even when focusing on one single technique and one well-defined cell type, measured cell stiffness seems to inherently display a very broad, non-Gaussian spread [ 260] (some approach this problem by averaging over many cells using larger samples [ 277]). Figure 21 shows typical measurement curves for a selection of four different methods.
To approach this, we measured cell growth of wild-type yeast cells treated with different amounts of fluconazole ranging from 16 to 128 μg/ml either in the absence or in the presence of sublethal concentrations of CR, CAS or ZYM (30 μg/ml, 15 ng/ml and 64 U/ml, respectively).
An aim of this study, therefore, was to measure cell mechanical behavior of wild-type and vinculin mutant cells under higher mechanical loads.
(b) Shotgun MS signals measured in cell types used as sources for IPs.
