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Indeed, the gold standard for measuring therapeutic benefits of pharmaceutical therapies is measuring bone mass typically with DEXA or pQCT.
Traditional epidemiologic studies of osteoporosis include analysis of bone fracture incidence and prevalence, while clinical methods include measuring bone mass or BMD.
Additional 109 studies were found irrelevant to the original research question and excluded because the disease of interest was either type 1 or gestational DM (81 studies); or for not measuring bone mass using DXA, i.e. by single X-ray absorptiometry, CT or ultrasound (28 studies).
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We measured bone mass, size, geometry, architecture, and strength in bones from three different genetic mouse models (Sost knock-out, Lrp5 A214V knock-in, and Lrp5 G171V knock-in) of HBM.
The problem is how you measure bone mass.
and those that used other methods to measure bone mass.
Several methods have been used to measure bone mass, including dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography.
The assessment of fracture risk often relies primarily on measuring bone mineral density, thereby accounting for only a single pathology: the loss of bone mass.
Thiele et al showed that locally measured bone morphometric parameters like cortical bone mass, cortical thickness and bone density can explain more than 80% of the pull-out strength at the proximal femur [ 13].
We conclude that the measure of bone mass needs to be supplemented with measures reflecting the physicochemical status of mineral crystals for improved assessment of fracture susceptibility.
The measures of bone mass and architecture need to be supplemented with physicochemical and compositional measures for better assessment of fracture risk.
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