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It is likely that Mrs May's measures will be tested in court, with unpredictable outcomes.
Outcome measures will be tested using a mixed effects repeated measures analysis with the primary factors being Time as a repeated measure, tDCS condition (sham or active) and Diagnosis (unipolar or bipolar).
The validity of both measures will be tested.
These measures will be tested one by one on their correlation with the quality of the referral letter.
After assuming an autocorrelation of data r = .30, changes over time in continuous measures will be tested by paired t-tests.
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Within the second meeting, the selected ergonomic measure will be tested by the construction workers in a test environment without any financial risks.
Secondary measures will be tests of risk of falling, additional measures of mobility, strength and flexibility, quality of life, fall-related self efficacy, health-system and community-service contact, assistance from others, difficulty with daily tasks, physical activity levels and adverse events.
Continuous secondary outcome measures, if normally distributed, will be tested using a Students' t-test, otherwise Mann-Whitney tests will be employed.
As secondary outcome measures, the anti-inflammatory effects of minocycline and aspirin will be tested by measuring pre-treatment and post-treatment levels of C reactive protein and inflammatory cytokines.
For the analysis of our first primary outcome, at-work productivity measured as a continuous variable will be tested for normality using the Shapiro-Wilk test [ 43].
Hypotheses 2 4 will be tested by measuring the changes in the mHCCQ, PCS, and PAEI scores, respectively, for patients seen by clinicians in Group 1 in the post-intervention period (immediately post and at one year) compared to baseline.
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