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Both impairment latent variables displayed strong, statistically significant path coefficients toward the measured variables, providing evidence that the measures we chose adequately tap into the proposed impairments.
As primary outcome measures, we chose the Mental State Attribution Task MSATT; Brüne 2003) to measure visual cognitive ToM, and the Reading the Mind in the Eyes Test (RMET; Baron-Cohen et al. 2001) to measure visual affective ToM.
As the acute phase measures we chose the CD4+ T cell level at nadir and the peak viral load.
41– 44 For the DTI measures, we chose to focus on FA as this is the most commonly altered DTI measure in the ALS literature.
From the array of reliable and valid measures we chose, for comparison, two whose dimensions looked fairly similar to our own.
To improve reliability of the measures we chose the highest of two values reproducible within 150 ml for FEV1 and FVC.
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They are the basis of the silhouette coefficient measure we chose [31].
Although one can invoke many reasons for why the phenotypic outcome measure we chose failed, the exercise was empirically informative by suggesting that a new transplantation model will likely need to be developed.
As distance measure, we chose 1- r UV.
Another important issue is the choice of primary outcome measure; we chose lung function because it was more objective and because the study could not be double blinded.
Although Ka/Ks > 1 is typically the standard by which positive selection is measured, we chose 1.5 to give more weight to our initial analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com