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MRI measures tissue iron concentration indirectly by detecting the paramagnetic influences of storage iron (ferritin and hemosiderin) on proton resonance behavior.
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15 Langkammer et al. measured the tissue iron content by inductively coupled plasma mass spectrometry during autopsy.
We therefore utilized an analytical cross-sectional methodology to evaluate whether common types of alopecia in women are associated with decreased tissue iron stores, as measured by serum ferritin.
The latter also leads to increased adipose tissue iron content, thus producing preconditions for adverse effects of local iron overload.
Iron chelation therapy with deferoxamine enhances iron excretion and removes excessive tissue iron in regularly transfused patients with sickle cell disease.
Mean R2 values for samples of ferrimagnetic-particle-loaded liver dissected into approximate 1 cm cubes were found to linearly correlate with tissue iron concentration over the range from approximately 0.1 to at least 2.7 mg Fe/g dry tissue when measured at room temperature.
Interestingly, that same year another article was published linking high tissue iron stores with Alzheimer's disease as well.
Functional iron deficiency anemia is adequate tissue iron defined as a serum ferritin level ≥100 ng/ml and a reduction in iron saturation.
Hepcidin regulates iron concentration and tissue iron distribution via the inhibition of intestinal absorption, released by macrophages and iron mobilization from hepatic stores [ 39].
Their values for QSM and tissue iron content were used to extrapolate the brain iron content for our patient.
This process is central for systemic iron supply as well as tissue iron detoxification (Tang and Zhou, 2013b).
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