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Further studies of cognitive domains most affected, such as attention, may provide more useful measures than overall IQ for defining clinically relevant subgroups.
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Such new clinical trials require alternative endpoints that can capture the effect of several treatment lines and be measured earlier than overall survival to help shorten the duration and reduce the size and cost of trials.
Measures that assess the within cluster performance – i.e. performance per cluster – will be probably more informative than overall measures, since prediction models are to be used by individual clinicians or treatment centers.
In contrast, for the AA subgroup, all measures of central adiposity ranked higher in predicting diabetes than overall obesity measures.
Much of the testing they undergo now is to measure race fitness more than overall health.
If we naively calculated the peak catch from the entire available catch trajectory we would be more likely to be measuring local peaks (rather than overall peaks) with fisheries that started more recently.
Obesity is defined on the basis of body mass index (BMI); however, definitions of the metabolic syndrome use measures of central obesity rather than BMI on the basis that central obesity (in particular visceral fat accumulation) is a more accurate measure of cardiovascular risk than overall excess bodyweight (Prineas et al. 1993; Rimm et al. 1995; Lakka et al. 2002b).
This measure is less sensitive than overall mutation frequency since some mutations detected more than once may be the result of independent events rather than clonal outgrowth, but using this end point assures that the observed unique mutations are truly derived from independent events.
In conclusion, we found no strong evidence that anthropometric measures of central adiposity were more predictive of diabetes than measures of overall obesity in the nHW and HA populations.
Interestingly, heritability estimates for intercuspal distances of molar teeth, which may be more biologically meaningful phenotypes than overall crown measures, are only moderate in magnitude.
Those taking vitamins along with the lutein did slightly better on overall measures than those taking lutein alone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com