Sentence examples for measures sequence conservation from inspiring English sources

Unlike all previous methods, our method measures sequence conservation based on discontiguous sequence similarity [ 27], which greatly expands the range of the conserved sequences.

Previously, the quality-score (that measures sequence conservation [ 20]) has been investigated and was found to have the tendency to underestimate remnant segments.

To calculate the correlation between miRNA expression and sequence evolution, we used two measures: sequence conservation among vertebrates and sequence variation within humans.

If we measure sequence conservation by considering the similarity of pairs of conserved segments only, the discontiguous sequence similarity, we may identify both types of conserved CRMs shown in Figure 2. Note that discontiguously conserved regions do exist, and the conserved segments in discontiguously conserved regions often contain conserved TFBSs.

Traditional methods measure sequence conservation without considering the conservation background of the protein.

Current studies often measure sequence conservation based on every position in contiguous regions.

Here, we measured sequence conservation for each amino acid site by calculating a normalized evolutionary rate from a global multiple species alignment in UCSC genome browser [ 21].

Aside that, the diversity of sequence predictors with different sequence property measure (sequence conservation, secondary structures, globularity, complexity) also allow for a multi-dimensional coverage of fold-critical residues.

If we measure sequence conservation by considering the similarity of two regions based solely on global alignments of the two regions, the contiguous sequence similarity, we can often only identify the conserved CRMs such as the one in Figure 2a.

Although evolutionary models at the nucleotide level are the methods of choice for measuring sequence conservation, these models are not easily applied to hypermutable genomic elements which are difficult to align.

To test whether coiled-coil regions carry phylogenetic information, we measured sequence conservation of coiled-coil regions and compared it with globular domains in a collection of over 2,000 orthologous groups of metazoan proteins.