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The multifocal electroretinogram (mfERG) is a non-invasive objective technique that simultaneously measures retinal function at multiple retinal locations.
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Thus, a reproducible method of measuring retinal function is needed to more accurately assess the response of macular edema to treatment.
This indicates that prior to the development of an overt phenotype as measured by retinal function, cGMP levels are already elevated in mutant mice.
The first test performed was ERG, which provides a gross measure of retinal function and an indication of relative rod and cone efficacy.
The electroretinogram (ERG) has been utilized as a measure of retinal function for over 100 years and reflects the massed retinal response following stimulation by light.
A modified MP-1 microperimeter can be used to measure scotopic retinal function, creating results which are comparable to the modified Humphrey field analyser.
While the b-wave is accepted as a reliable measure of overall retinal function, the a-wave is generated more specifically by the photoreceptor cells.
Similarly, visual acuity (VA) is considered as the gold standard in assessing retinal function.
To propose an analytic framework for ocular fundus alterations in late-stage Vogt-Koyanagi-Harada (VKH) disease, to describe the characteristics of overall retinal function as measured with full-field electroretinography (ERG), and to correlate the intensity of the fundus changes with full-field ERG alterations and to stratify patients accordingly.
Blockade of TGF-β signaling led to increased vascular and neural cell apoptosis in the retina, which was associated with decreased retinal function, as measured by electroretinogram (ERG).
Of particular interest for the treatment of inherited retinal degenerations, subretinal delivery of these nanoparticles transfected nearly all of the photoreceptor population and did not cause irreversible defects in retinal function (as measured by electroretinogram (ERG)) [14].
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