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22 23 We examined diagnostic two by two tables and diagnostic performance measures per study (sensitivity, specificity, predictive values).
The types of measures reported, proportion of studies reporting ≥2 measures and mean (±SD) number of measures per study were determined for all studies and compared between subgroups.
Our analysis also demonstrated AF studies (compared with VTE studies), observational studies (compared with randomised trials) and more recently published studies (2004 2013) (compared with older ones) were more likely to report ≥2 VKA control measures per study and report a greater absolute number of measures per study.
Thus, the study data consisted of five subjects with the full set of repeated measures per study arm, partial data from the porter who resigned, and the temporary porters.
Data are reported here for the 34 participants who submitted a sufficient number of PC-based test data sets to allow reliable analysis of both study phases (at least 8 measures per study phase).
Moreover, the AF, observational and later time period study subgroups were also more likely to report a greater absolute number of measures per study (p<0.02 for all comparisons).
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We scaled our measure by s, giving, effectively, a per study measure of recovery and non-recovery in order to make an unbiased comparison among ecosystems and perturbations for which there are different numbers of studies.
Most studies used measures from three core health areas (physical, mental, social health), but the number of measures that were used ranged from one measure per study up to 34 outcome parameters in one study.
Methods of meta-analysis that allow for different outcomes (and different numbers of outcomes) to be measured per study, such as that of Gleser and Olkin [ 18], or DuMouchel [ 19], may be used to implement the POR model.
Rather than using a single outcome measure per study, like the diagnostic odds ratio in the summary ROC approach, the bivariate model preserves the two-dimensional nature of diagnostic data by directly analysing the logit transformed sensitivity log sens/ 1-sens)) and specificity log sens/ 1-sens)) of eand specificitysinglog spec/ 1-spec
Among observational studies, the median number of measures satisfied per study was 5 (range 2 to 9), and among clinical trials was 4 (range 2 to 7).
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