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They provided a total of 360 olanzapine concentrations (1 to 11 measures per patient).
A maximum of 12 measures per patient per day were performed, and measures could be registered over several days.
Intraclass correlation coefficients and 95%% confidence intervals (CI) were estimated using a single pair of measures per patient.
Overall, 119 different measures were analyzed with a mean of 5 per patient ranging from 1 to 12 measures per patient.
For comparisons between ECMO days with and without bleeding, to account for the repeated measures per patient (with bleeding recorded on each day of ECMO treatment), a repeated measures mixed model was performed for continuous variables and random effects logistic model for binomial variables.
To account for the repeated measures per patient, variables that were found to be independently associated with the bleeding outcomes in the stepwise logistic model were then included in a multi-level logistic regression model, with each patient now modelled as a random effect.
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We decided to use a "cost per patient affected" as the numerator in the cost-value ratio in future implementation: with all costs measured on the per patient level, the cost-value ratio becomes a fairer comparator.
The main outcome measure was the per patient annual financial cost benefit of twice-daily compared with the traditional twice-weekly consultant ward rounds over a 2-year period.
For patients of group 2, the perpendicular depth to the 125I seed, which was used for US-guided injections as well, was measured per patient, and the optimal injection location was marked on the skin.
Up to 26 PSA levels measured per patient were divided into each patient's training set and his validation set.
6 I decide in this case to do this by selecting one measure per patient.
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