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To achieve this goal the MRI measurements of tumor perfusion were compared to quantitative measures of vessel density and tortuosity with microfocal computed X-ray tomography and molecular marker of vascular morphology.
This requires automated systems that extract quantitative measures of vessel morphology from large numbers of retinal images.
Metrics compared include vascular density and two measures of vessel tortuosity quantified from segmentations of vessels traversing and surrounding 24 tumors and abdominal vessels from control mice.
Other outcome measures include electrocardiography, echocardiography and measures of vessel wall stiffness (PWV and carotid distensibility) [ 10].
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To obtain an accurate measure of vessel angle with respect to the imaging beam, we acquired 3-D volumes of the myocardium along the vessel and measured the vessel displacement along the optical axis (z) from the OCT intensity images.
The scores that can be used to describe numerically the microcirculatory images consist of the following: a measure of vessel density (total and perfused vessel density; two indices of perfusion of the vessels (proportion of perfused vessels and microcirculatory flow index); and a heterogeneity index.
Any potential anti-angiogenic effects were interrogated using susceptibility contrast MRI with intravascular ultrasmall superparamagnetic iron oxide (USPIO) particles, enabling steady-state determination of the tumour fractional blood volume (fBV, %) and vessel size index (VSI, μm), a weighted average measure of vessel calibre (Tropres et al, 2004; Walker-Samuel et al, 2012).
Total vessel density (TVD), perfused vessel density (PVD), valid vessel density (VVD) and De Backer Score were calculated as measures of microvascular vessel density; the percentage of perfused vessels (%PV) was calculated as the number of vessels continuously perfused divided by the total number of vessels of the same type.
An operator's investment in the fishery was estimated on the basis of a measure of vessel-capacity that had been used earlier in the management of the fishery.
Using the Illumina HumanExome BeadChip, we investigate the association of single-nucleotide polymorphisms and variants collectively across genes with summary measures of retinal vessel diameters, referred to as the central retinal venule equivalent and the central retinal arteriole equivalent.
The purpose of the present study is to better understand the complex relationships between MRI measures of small vessel disease, atrophy, and cognition in patients with sporadic Alzheimer's disease (AD) and cognitively normal elderly controls (NCs).
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