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Significant improvements in tinnitus severity, but not in objective psychometric measures of tinnitus loudness, occurred in both treatment groups, however a greater effect was observed in the TRT group compared with the control group.
A small but significant number of subjects reported decreased tinnitus annoyance that corresponded with a decrease in objective measures of tinnitus loudness during active drug treatment with a washout effect during placebo treatment.
Psychoacoustic measures of tinnitus were not identified here.
Associations between behavioural measures of tinnitus and electrophysiological markers have repeatedly been reported before [ 54– 54].
Sprague Dawley rats were used to obtain behavioral measures of tinnitus, hyperacusis, and acoustic startle reflex amplitude-intensity functions.
Animal studies measuring correlates of hearing loss and putative behavioral measures of tinnitus have found increased cortical neural synchrony [ 14] and a possible thalamic origin to this [ 11].
Similar(52)
We found that gap-detection deficits, a behavioral measure of tinnitus, were 5 times stronger and lasted 10 times longer when isoflurane was not used.
Therefore, a more robust measure of tinnitus is highly desirable.
Only four studies used a psychoacoustic measure of tinnitus percept, namely, tinnitus loudness [ 40, 42, 43], pitch match [ 41], and minimum masking level [ 42].
Overall, five out of six studies reporting some type of self-reported outcome measure of tinnitus handicap or severity demonstrated a positive benefit of training.
Such a viewpoint would suggest a psychoacoustic measure of tinnitus (such as tinnitus loudness or minimum masking level) as the primary outcome measure rather than a self-reported measure (such as a reduction in tinnitus distress).
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