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Moreover, circulating T4 levels and T4 T3 ratios have been used as measures of thyroid status; however, T4 is generally regarded as a relatively inactive precursor of T3 (Eales et al. 1992) and it was not found to correlate with growth in kutum (unpublished data).
There are no studies with individual measures of thyroid function and these goitrogens available in infants.
Measures of thyroid function (levels of thyrotropin, total and free triiodithyronine, and thyroxine) are conducted following standard laboratory procedures.
Although the results have been inconsistent, differences in the exposure matrices, timing of measures of thyroid hormones, PCB congeners measured, and statistical methods make direct comparisons difficult.
It is possible that breast-feeding has a beneficial effect, reducing the impact of prenatal PCB exposure on measures of thyroid function.
Each of these studies evaluated various measures of thyroid function and either assigned perchlorate doses or collected serum or urine samples that could be used to quantify perchlorate exposure.
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The TSH test measures the amount of thyroid hormone the pituitary is secreting.
Therefore, we focused on treatment with l-thyroxine or antithyroid agents as a measure of thyroid dysfunction.
The level of serum thyroxine (T4) was not a sensitive measure of thyroid deficiency.
In addition, we used TFI as a surrogate measure of thyroid function.
The outcome measures were prevalence of clinical and subclinical hypothyroidism and thyroid function index (TFI) – a measure of thyroid function.
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