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Three measures of potency are explored and shown to be highly correlated.
We find that classical measures of potency such as the IC50 may be functions of viral life-cycle kinetics.
However, other measures of potency, such as area under the curve (AUC), were not considered to see whether increasing the binding rate resulted in increased potency in general.
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As a measure of potency, we will refer to EC50 hereafter.
Given that high intra-family PCAIN correlation scores and low inter-family PCAIN correlation scores are necessary for defining a refined fold signature with high SNR, the difference between these two scores provides a reliable measure of potency.
RPFs for all like-acting chemicals are scaled relative to chlorophos by calculating the ratio of a common measure of potency, such as the dose concentration (U.S. EPA 2000).
The consequent sustained reductions in Isc exhibited an EC50 of 5.7 μM (2.2 14.6 μM) in WT mouse colon, consistent with a previous measure of potency at mouse Gpr119 receptors (7.9 ± 0.7 μM) (Overton et al., 2006).
A likelihood ratio chi-squared test provided the same repeated measures assessment of potency frequencies between baseline and 24 months after treatment.
Pharmacological tools and techniques are designed to determine system-independent measures of the potency and efficacy of drugs.
There are pharmacological tools and techniques designed to determine system-independent measures of the potency and efficacy of drugs, but to apply them effectively, the molecular mechanism of the drug must be known beforehand.
The delayed cellular effects of DOT1L inhibition challenge the miniaturization of cell-based measures of compound potency.
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