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Accurate measures of phthalate exposure are needed to assess their human health effects.
Restricted cubic spline curves were used to assess the relationship between continuous measures of phthalate and BPA levels and cord blood adipokines.
Measures of phthalate metabolites in the urine are informative as internal dosimeters of exposure because urinary enzymatic activity is negligible (Kato et al. 2004).
To our knowledge, no previous studies have evaluated mammographic breast density in relation to biological measures of phthalate, paraben, or phenol exposures.
Second, we collected two measures of phthalate metabolites during pregnancy, which allowed us to reduce some of the within-person variation of these exposures and examine distinct windows of vulnerability.
First, collinearity between the repeated of measures of phthalate metabolites may be an issue because it may lead to inflated standard errors and plausibly change the direction of estimates of β j s [ 13].
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We also do not have measures of phthalates in participant's indoor environments, a potential source of exposure particularly in this age group.
The primary aim of the current study was a) to use biomarkers of exposure (i.e., metabolites measured in urine) to evaluate variability in phthalate concentrations in pregnant women; and b) to evaluate variability in measures of phthalates in their external environment (i.e., indoor air).
These biomarkers represent an integrative measure of phthalate exposure from multiple sources and pathways.
Specifically, metabolites of DEHP were negatively associated with IGF-1 among boys, whereas a cumulative measure of phthalate exposure (encompassing DEHP metabolites, MEP, and MBP) was negatively associated with triiodothyronine in girls.
MNG formation is a convenient measure of phthalate-induced effects on the seminiferous cords (Boekelheide et al. 2009; Howdeshell et al. 2008).
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