Sentence examples for measures of pathway from inspiring English sources
Significantly, in a xenograft model of delayed tumor fixation, HER3 phosphorylation is unstable, while alternate measures of pathway activation, such as formation of the HER3PI3K complex is preserved.
The challenge here will be to develop and validate sensitive and specific measures of pathway perturbations and environmental exposures to encompass biomarkers of both exposure and response.
Some quantitative measures of pathway biomarkers (e.g., genes, proteins) may be needed to determine the dominant interactions in specific feedback or feedforward motifs.
We believe this reflects the complexity of these cell signaling pathways combined with the power of the signature development approach whereby the capacity to sample a diverse array of expression values can yield measures of pathway activity.
Each data set was scored against network models representing different aspects of inflammatory signaling and cell cycle progression, and these scores were compared with independent measures of pathway activity in NHBE cells to verify the approach.
Therefore, not unexpectedly, metabolic measures of pathway specificity (such as HDL subclasses) can provide far better insights into biological processes than common clinical measures representing merely a sum of multiple biochemical components (such as HDL cholesterol).
It enables calculation of the Pathway Activation Strength (PAS), a value which serves as a qualitative measure of pathway activation.
GSA-SNP analysis implements a computationally efficient measure of pathway association from GWAS SNP p-values by Z statistic.
The Z-statistic method is a parametric measure of pathway association [ 7] without requiring permutation; however, the test requires an assumption of gene-set independence.
To find an actual measure of pathway similarity, the Jaccard coefficient and distance are used as shown in (6) and (7).
Our method can then assess the degree of statistical similarity between gene expression profiles in human disease and these pathway signatures, which in turn can be used as a measure of pathway activation.
