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The method, which we call One Biallelic Marker Approximate Bayesian Computation, makes use of experimental data consisting of periodic measures of neutral marker frequencies and mean population fitness.
We also found consistent increases in measures of neutral genetic variation from before to after the disturbance (see Table 1 and Fig. 5).
The 10th and 90th percentiles of the angular elevation distribution have been reported in many studies as measures of neutral and extreme postural exposures, and variation has been quantified by the 10th-90th perangeile range.
Our analysis of Fish Lake compared to the other 26 populations in our study indicates that it ranked 5th overall with its distinctiveness driven largely by the measures of neutral genetic variation rather than by morphological distinctiveness (Table 3).
The availability of a map of long-range chromatin structure across the human genome [ 1] allows us to assess this idea and, through the comparison of various measures of neutral variation, we have identified those forms of chromatin structure associated with the highest rates of background mutation.
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Following Margulies et al [ 14], we consider the distribution of sequence identity in repeats as a measure of neutral divergence.
As a measure of neutral divergence between the two N. tetrasperma strains, we calculated the number of synonymous substitutions per site (Ks) for each gene within each rearrangement event.
In each region we compare the proportion of divergent TFBS/miRNA target sites with the amount expected given the over-all sequence divergence of the opsin BACs and introns (a measure of neutral evolutionary divergence [ 42, 43]).
In an alternative approach, one can avoid archaeological dates as calibration points and instead measure the time using the amount of neutral variation that is expected to accumulate in a clock-like manner.
For the reasons stated above, we believe that our evolvability index is fundamentally different from these measures of predominantly neutral evolutionary change.
Theory suggests that the number of independently segregating loci is crucial to the accurate estimation of the population genetic parameter θ (4Ne μ) [14], [17], which is usually interpreted as a scaled measure of the neutral mutation rate per site or as the proportion of polymorphic sites in a population [19].
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