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The |D'| and r2 measures of linkage disequilibrium were calculated using the program Haploview v4 [29].
Measures of linkage relationships between the six loci and the centromere were obtained to quantify the relationship between relative sequence diversity and chromosomal position.
Lewontin's D prime (D') and the correlation coefficient (r2) were calculated as two measures of linkage disequilibrium (LD) between CRP polymorphisms among control participants.
In the simulations we have not considered the possible impact of natural selection and its consequences both on the estimated taxes of recombination (as they rely on measures of linkage disequilibrium) and on FST measures.
Measures of linkage disequilibrium (LD) were calculated within haploview.
Lewontin's D prime (D') and correlation coefficient (r) were calculated as two measures of linkage disequlibrium.
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Wray, N. R. Allele frequencies and the r2 measure of linkage disequilibrium: impact on design and interpretation of association studies.
We suggest a metric which quantifies the level of association between loci-effectively a measure of linkage disequilibrium.
Finally, we use r2max to examine the connection between r2 and the D′ measure of linkage disequilibrium, finding that r2/rmax2="D′2 for ∼72.683% of the space of allowed values of (pa,pb,pab).
This view was however strongly debated with criticisms about the quality of the data and about the measure of linkage disequilibrium used [63] [67].
Association testing for the haplotypes as well as the measure of linkage disequilibrium (D') between all pairs of SNP's was performed using the same software.
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