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They gave an exact characterization of the distribution to which suitably scaled measures of instability converge have been defined, based on a sample drawn from any distribution in a satisfying mild regularity conditions.
We calculated measures of instability at the matriline-level in seven groups of captive rhesus macaques.
Breakpoints inferred from array CGH data were previously used to assess genomic instability in combination with other measures of instability such as a fraction of the genome altered [ 17].
LBP screening questionnaire [ 28] PASS-20 (Pain Anxiety Symptom Scale) [ 29] Pain Self Efficacy Questionnaire [ 30] International Physical Activity Questionnaire (IPAQ) [ 31] Three minute step test [ 32] As no in-vivo measures of "instability" have been validated assessment of instability is currently dependent on subjective data.
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The mean distance between this mean set and the others is taken as a measure of instability.
For each strain, the distance between it and all other strains was calculated for each tree pair, and the sum of all distances is the measure of instability.
BPI instability is correlated with commonly used measure of instability, the proportion of genome altered and it may have a prognostic value as well.
It provides a measure of instability in health (which may be a consequence of frailty) and is believed to be a marker of imminent decline in health.
This limited understanding is due both to the genomic heterogeneity in different tumor types as well as within individual tumors and a lack of methods capable of capturing both the state and rate of instability, which are required to determine the true measure of instability.
The detailed quantified phenotype that is, the composite measures of mood instability, comorbid anxiety, and multiple drug addiction, beyond the SCID-confirmed bipolar disorder subtype represents novel composite quantifications and may provide more detailed clinical disease characteristics that can be used in future biomarker genomic studies.
Therefore, we defined a number of different measures of genome instability and analysed their correlation with patient outcome using the TCGA data set (Table S5).
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CEO of Professional Science Editing for Scientists @ prosciediting.com