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Measures of hyperglycemia were not significantly associated with WM structure when covaried for age.
In addition, measures of hyperglycemia and glucose variability were significantly associated with WM structure, although measures of hypoglycemia were not.
Significant associations of AD, RD, and FA were found for CGM measures of hyperglycemia and glucose variability but not for hypoglycemia.
In these unadjusted analyses, we observed associations between some of the glycemic markers and prevalent chronic kidney disease, albuminuria, and retinopathy, but these results were variable across the different measures of hyperglycemia (Tables 2 and 3).
Clinical trials with DPP-4 inhibitors have now been reported for all these patient groups and have demonstrated significant improvements in measures of hyperglycemia, with a good safety profile.
In patients with type 2 diabetes mellitus, SGLT2 inhibitors have been found to consistently reduce measures of hyperglycemia, including hemoglobin A1c, fasting plasma glucose, and postprandial glucose, throughout the continuum of disease.
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To examine the association of hyperglycemia, as measured by GHb, with subsequent mortality in a nationally representative sample of adults.
While we utilized only one measurement of fructosamine as a measure of hyperglycemia, this measurement was taken at the time of other baseline measures (on average 5 months post-diagnosis) and baseline lifestyle questionnaires.
HbA1c is a relatively long-term measure of hyperglycemia that is subject to less measurement error compared with other biomarkers of glycemia (34).
AGE accumulation is not just a measure of hyperglycemia, but represents cumulative metabolic burden (both hyperglycemia and hyperlipidemia), oxidative stress and inflammation [ 5].
With this approach, the CGM measure of hyperglycemia, AUC180, was significantly negatively associated with FA values in widespread regions of the brain [ t(127) = 1.62, P < 0.05].
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