Note that metabolomics measurements only provide semiquantitative measures of glucose in urine.
In the present study, in the DPS population rs6772767, rs490683 and rs509035 were associated with several measures of glucose metabolism over four consecutive measurements.
Relatively straightforward measures of glucose variability include the direct measurement of postprandial glycaemia, the mean blood glucose level and its standard deviation.
After a 90-s adaptation period, the experimenter reentered the room and recorded baseline measures of glucose.
Current users of oral contraceptives did not have elevated values for any of the four measures of glucose metabolism.
Objective: This study was undertaken to determine whether users of oral contraceptives in a nationally representative population of US women had elevated levels of measures of glucose metabolism.
This finding is in some discrepancy with the association shown with measures of glucose metabolism.
Rs490683 and rs509035 were associated with several measures of glucose and insulin metabolism during the follow-up.
At baseline, no significant associations with measures of glucose metabolism and the seven genotyped GHSR polymorphisms were observed (Table 1 for rs490683, data not shown for other SNPs).
Rs490683, which was associated with weight loss and measures of glucose metabolism, is in strong linkage disequilibrium (LD) with rs509035 (Fig. 1B).
The observed concordance of several related but independent phenotypic measures (e.g., measures of glucose response during an OGTT, measures of insulin response during an OGTT, and T2DM diagnosis) with the same allele provides important internal replication of the association.
