Your English writing platform
Discover LudwigExact(59)
A better test of the key prediction of our model, that genes replicated early will be expressed more frequently than genes replicated late, would involve empirical measures of expression from each of these ortholog families.
We use two measures of expression: breadth of expression (the number of tissues in which a gene was expressed) and maximum expression level among tissues (the highest value of expression of a gene among tissues).
Supplementary Figure 1 Measures of expression of signature genes across TCGA breast cancer dataset.
We investigated the relationships between our three measures of expression.
Because 'omics' measures of expression are usually on an arbitrary scale, we chose to evaluate ratios or their equivalent differences on a log scale [15].
Additionally, we used the same experimental design and same samples to generate measures of expression for Affymetrix U133Plus2, thereby allowing an unbiased comparison of the two platforms.
Because the measures of expression level and expression breadth are highly correlated with each other (see Figure 2) we reconsidered the effects of either of the two measures on gene sequences after correcting for the other.
Thus it could be that multiple factors are at play and that the coding sequence and noncoding sequences are not related to the different measures of expression for the same reasons.
Specifically, we compare the measures of expression for HuEx and U133Plus2 arrays to evaluate the precision of these measures as well as the specificity and sensitivity of the measures' ability to detect differential expression.
Further studies will be necessary to define the biological role of these genes in proteinuric kidney disease and to determine if measures of expression of these genes are predictive of long-term clinical outcome.
Similar(1)
Importantly, as defined here, the measure of expression consistency is expected to be biased toward generating higher estimates for highly expressed and long genes.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com