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This paper uses measures of episodic memory and verbal fluency as indicators of cognitive function [19].
CSF tau/Aβ42 was associated with baseline performance on 5/9 neuropsychological measures, especially measures of episodic memory, and longitudinal performance on 7/9 neuropsychological measures, especially measures of global cognition.
Results were congruent with the previous meta-analytic findings indicating that carriers of ApoE allele 4 (ɛ4) perform significantly worse on measures of episodic memory, executive functioning, and overall global cognitive ability.
In contrast to earlier studies, the results also indicate that increases in age result in significantly larger differences between ApoE ɛ4 carriers and ApoE non-ɛ4 carriers on measures of episodic memory and global cognitive ability.
Odour identification scores correlated positively with scores on cognitive measures of episodic verbal learning (r = 0.30, P < 0.05).
A number of studies have shown that activity in lateral parietal cortex covaries with a number of measures of episodic memory strength (Wagner et al. 2005).
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The free recall portion of the Free and Cued Selective Reminding Task (FCSRT-free) detected declining cognition in the high CSF tau/Aβ42 group the earliest, followed by another measure of episodic memory and a sequencing task.
As a measure of episodic memory, all participants performed the memory task from the neuropsychological test battery of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD; [ 21]).
All participants in this cognitively normal cohort were administered a common battery of psychometric tests, including Selective Reminding (a measure of episodic memory) (Grober et al, 1988), Animal Naming (assesses semantic memory) (Goodglass & Kaplan, 1983) and a speeded visuospatial test with two parts: Trailmakings A and B (Armitage, 1946).
Further, heavy cannabis use negatively correlated with gray matter in human hippocampus (Yucel et al., 2008) while moderate cannabis use was associated with reduced performance on a logical memory task, that is generally considered to be a measure of episodic memory (Indlekofer et al., 2009).
In the present study, we report on the cognitive differences by age periods on IQ and on the free recall measures of verbal episodic memory and visual episodic memory.
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