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Several measures of domain promiscuity exist (see Tab. 1).
Several measures of domain's network properties were introduced to evaluate the ability of a domain to form different combinations [ 11, 13].
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Secondary outcomes included performance on multiple measures of domain-specific cognitive function.
Thus, generic QOL scales are unlikely to be the most sensitive and specific measures of domains of QOL that are relevant to dementia patients.
Indeed as 82.5% of all TCS foci are either one-gene, one-domain foci, or two-gene, two-domain foci, measures of ' domains per focus' correlate with the ' % of paired TCS genes' and ' % of orphan TCS genes' measures.
Validity of patient scores in the second study was indicated by correlations between QOL-AD scores and several measures of domains hypothesized to be associated with QOL: behavioral competence, psychological status, physical function, and interpersonal environment.
Recognised standardised measures were used for ratings of the severity of symptoms and social problems and of risks, but these scales are very broad and global, and more differentiated and sensitive measures of domains such as psychotic symptom severity might have yielded significant associations.
We have shown that this measure has properties expected from a measure of domain versatility.
We adopted the weighted bigram frequency used by Basu (Basu et al. 2008) as a measure of domain promiscuity (π i ).
In summary, our measure of domain versatility indicates that a random attachment process is sufficient to explain the observed distribution of domain arrangements and that several views on domain promiscuity need to be revised.
Another approach is to obtain an experimental measure of domain formation, from FRET or excimer/monomer ratios (40, 41), and compare it with Monte Carlo simulations, varying ωAB in the simulations until a match is obtained.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com