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The delayed cellular effects of DOT1L inhibition challenge the miniaturization of cell-based measures of compound potency.
12 IMD scores are publically available continuous measures of compound social and material deprivation that are calculated using a variety of data including current income, employment, education and housing.
IMD scores are publicly available continuous measures of compound social and material deprivation which are calculated using a variety of data including current income, employment, health, education, and housing.
Similar(57)
Appropriately determined PGP efflux ratios can be used as a measure of compound affinity to PGP.
The first category is data fusion of similarity coefficients, in which several types of similarity coefficients take into account different characteristics of compounds that are combined together to optimize the measure of compound similarity [16, 17].
Curve ranks should be viewed as a numerical measure of compound activity.
Curve ranks should be viewed as a numeric measure of compound activity.
The library also includes multiple samples of many compounds, providing another measure of compound and assay variability.
The cell viability assay has been widely used as a measure of compound cytotoxicity (Xia et al. 2008).
As a measure of compound toxicity, parallel cytotoxicity plates were set up for which the virus was replaced with media and the cytotoxicity was monitored by MTS staining (Promega, Madison, WI).
To facilitate analysis, each curve class was combined with an efficacy cutoff and converted to a numerical curve rank (Huang et al. 2009) such that more potent and efficacious compounds with higher quality curves were assigned a higher rank, and inactive (class 4) compounds were assigned a curve rank of 0. Curve ranks should be viewed as a numerical measure of compound activity.
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