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The goal of our analysis was to evaluate the association between MRI measures of alignment and radiographic PF OA.
When parameterized for functional inference, quality control measures of alignment overlap and sequence identity result in clusters composed of sequences with the same domain architecture.
The four measures of alignment quality that we collected could each help predict in advance whether a given protein would be well-suited for use with our method.
We utilize a recently developed approximation algorithm for protein structure matching to demonstrate that a deep search of the protein superposition space leads to increased alignment accuracy with respect to many well-established measures of alignment quality.
In " On the difference in quality between current heuristic and optimal solutions to the protein structure alignment problem," M. Arriagada and A. Poleksic utilize an approximation algorithm for protein structure matching to demonstrate that a deep search of the protein superposition space leads to increased alignment accuracy with respect to many well-established measures of alignment quality.
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The standard deviation of the normalized vector angles was used as a measure of alignment, in which a highly aligned sample has a lower standard deviation of fiber angles (Fig. 3a), and a highly unaligned sample has a higher standard deviation of fiber angles (Fig. 3b).
S2, S6, S8, and by applying a similarity measure of alignment index) but also to look for consistent large-scale results in the group level (for review on the importance of this approach combined with single subject analysis see [65]).
I (A & S & T ) is used as the measure of alignment quality.
Given this measure of alignment quality, parameters were optimized with a simplex optimizer as previously described [ 57].
Both bias and standard deviation strongly depend on the fraction of anchors, which can be thought of as a measure of alignment quality.
NH is a common measure of alignment quality, counting the number of protein pairs belonging to the same homologous groups identified by the Homologene algorithm.
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