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For the 542 subjects with an NBAS exam at 2 weeks, we observed consistent inverse associations between cord serum PCB and DDE levels and NBAS measures of alertness, quality of alert responsiveness, cost of attention, and other potential attention-associated measures including self-quieting and motor maturity.
The attention network test (ANT) assesses the effect of alerting and orienting cues on a visual flanker task measuring executive attention.
No differences were found between the groups on RT and accuracy measures of the alerting, orienting, and conflict networks.
Secondly, we studied subgroups of adults with ADHD, expecting impairment on measures of the alerting and control networks in a subgroup with additional symptoms of affective fluctuations.
Individual NBAS items fell into three broad domains: a) measures of attention (alertness, quality of alert responsiveness and cost of attention), b) measures of state (consolability, self-quieting activity, hand-to-mouth facility, irritability and never in state to do orientation items), and c) measures of motor function (elicited and spontaneous activity, and motor maturity).
At the same time their results on the measure of the alerting network suggest that they were more alert.
The median cord serum level for subjects included in this analysis was 0.19 ng/g (range, 0.01 4.41 ng/g serum) for the sum of four prevalent PCB congeners and 0.30 ng/g (range, 0 10.27 ng/g serum) for DDE. Figure 1 shows inverse associations for the two PCB congener groups as well as DDE and measures of attention, including alertness, quality of alert responsiveness, and cost of attention.
Furthermore, recent studies have investigated the influence of meditation on tonic alertness using behavioural tasks that are specifically designed to measure alerting attention.
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