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It is important to emphasize that both fluorescence and electron microscopy methods do not provide direct measures of aggregation, because increases in receptor density after activation are likely to reflect nearby aggregates of various sizes that have coalesced into a "signaling patch".
Our goal was to reexamine these questions through use of a new structurally defined ligand, computation, and experimental measures of aggregation and signaling.
For example, localized measures of aggregation propensity (Bracken et al., 2001; Esteras-Chopo et al., 2005; Galzitskaya et al., 2006; Lopez De La Paz and Serrano, 2004; Romero et al., 2004; Thompson et al., 2006; Zbilut et al., 2004) might be used to design proteins less likely to form amyloid fibrils.
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The DLS detector count rate is a sensitive measure of aggregation due to its strong scaling with aggregate size, and it provides a less biased measure than the main number peak size determined by the built-in CONTIN algorithm.
The model will be compared with the measuring of aggregation of zero-valent iron nanoparticles in time.
A weak band appearing around 500 nm is a measure of aggregation of the RB molecules in solution (Xu and Neckers 1989).
An increase in platelet cluster size due to aggregation results in an increase in the FSC read out, and was used as a measure of aggregation.
When the set of 200 genomes was examined as a group, with an average measure of aggregation for each genome represented by a single data point, coding and noncoding regions formed different distributions of aggregation with noncoding regions shifted towards higher values of aggregation (Fig. 1).
Despite removing statistical effects of GC-content by recoding genomes in Purines and Pyrimidines, and using a measure of aggregation that is independent of the ratio of coding to noncoding DNA, GC-content, genome length (but not chromosome length), and percent coding DNA were significantly correlated with aggregation.
The distribution of phyla across the range of aggregation in this study strongly corroborates the pattern described by Bohlin et al. (2009) who examined the genomic fraction of purine and purine/pyrimidine stretches (i.e. an indirect measure of aggregation) in relation to environmental variables across a similar but smaller set of prokaryote phyla [19].
A negative binomial model was constructed and the value of alpha (a measure of aggregation) was used to describe clustering in susceptible individuals (i.e.aggregation).aggregation
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