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Current challenges in the cognitive assessment of MCI include: test selection, the availability of normative databases, and the effect of different base rates of MCI and AD in different settings; establishing cut-off points for impairment; and developing measures more sensitive to early AD while having sufficient specificity to distinguish between etiologically different conditions.
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"We tried to come up with a measure more sensitive to changes at the top which people are more interested in, and which is more intuitive," says Sumner.
In addition our analysis was limited to routinely collected laboratory parameters and we did not measure more sensitive markers of inflammation.
However, asthma-specific outcome measures are more sensitive than generic measures to disease-specific aspects of health-related quality of life and the effects of asthma treatments.
While structural neuromarkers were more predictive and less variable, functional MRI measures were more sensitive to domain differences.
Both have increased significantly, with the lesser horseshoe thought to have been helped by a series of mild winters and the greater horseshoe from agricultural conservation measures including more sensitive management of hedgerows and habitats around roosts.
All of the following analyses on arm azimuth data were conducted using data from the nearest target distance trials (1.3 m displacement) due to the fact that arm azimuth measures are more sensitive for targets within closer proximity.
These speech subsystem measures are more sensitive than current best practices for detecting subclinical changes in bulbar motor performance.
Also, subjective measures are more sensitive to changes in the participants' frame of reference, i.e. their perception may change over time, for instance, because they have put a certain condition or state into perspective.
Additional studies that include both subjective and objective sleep measures and more sensitive methods of glycemic status should be conducted to address the issue of long-term sleep restriction and diabetes.
This feature, in contrast to the average pause length measure, is more sensitive to a difference in the amount of time spent in a pause period, relative to the time in active speech.
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CEO of Professional Science Editing for Scientists @ prosciediting.com