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We extended the analysis of these compounds to PptT utilizing a recently published fluorescence polarization (FP) assay that measures modification of a CP target with a synthetic fluorescent CoA analogue (Table 1).
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Effect measure modification was assessed between concussion history and covariates.
We did not observe any effect measure modification of the volunteering crime involvement relationship by age or race.
We examined effect measure modification of the exposure outcome relationship due to participant demographic factors by including interaction terms of exposure (volunteering) and participant age, sex, and race.
We did not detect significant effect measure modification for timing of exposure.
First, our study was the only one to account for effect measure modification by MVL.
Significant interaction was defined at the p = 0.10 level, indicating effect measure modification and warranting subgroup analyses.
Where effect measure modification was present, we constructed interaction terms that were tested individually for statistical significance.
Effect measure modification was present between fisting/bleeding; fisting/consumption of NADs; fisting/group sex; and between group sex/consumption of NADs.
When effect measure modification was present among the remaining factors, we defined interaction terms that were tested for a statistically significant influence on the outcome parameter.
Second, because we had over 9,000 subjects and over 1,000 cases, we could explore effect measure modification (interactions) and estimate associations within subgroups of participants.
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