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To test unidimensionality and local independence of a set of shoulder functional status (SFS) items, develop a computerized adaptive test (CAT) of the items using a rating scale item response theory model (RS M, and compare discriminant validity of measures generated using all items (θIRT) and measures generated using the simulated CAT (θCAT).
To develop computerized adaptive tests (CATs) designed to assess lower extremity functional status (FS) in people with lower extremity impairments using items from the Lower Extremity Functional Scale and compare discriminant validity of FS measures generated using all items analyzed with a rating scale Item Response Theory model (θIRT) and measures generated using the simulated CATs (θCAT).
Quality of the arrays was assessed using histograms of probe intensity, RNA degradation plots and Affymetrix-style quality control measures generated using functions within the affy and simpleaffy package of Bioconductor [54].
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Sun sensitivity is a dichotomous measure generated using factor analysis of six correlated variables related to sun sensitivity (see Supplementary Data).
Using ArcGIS (v9.3, ESRI, Redlands, CA, USA), individual maps of parasite rates and rates of uptake of control measures were generated using inverse-distance weighting to smooth surfaces across unmeasured locations between survey clusters.
Network maps and component and density measures were generated using the program Ucinet [ 16].
Data were normalised and probe intensity measures were generated using the Robust Microarray Analysis algorithm (Irizarry et al, 2003).
Adjusted rate ratios (incidence rate ratio (IRR) and 95% CI) between the burn injury and no injury cohorts and the outcome measures were generated using negative binomial regression.
For each individual measure (e.g. smoking, income, etc)., and for the combined factors, a cumulative measure was generated using data from both waves of survey data such that each mediator could take a value of 0, 1 or 2, with higher scores representing more negative material, psychological or behavioral exposures.
Aliquots of the starting material, spin supernatant, and the resuspended vaults were analyzed by MRM-LC-MS/MS, and the bryostatin 1 concentration was measured using a standard curve generated using known concentrations of bryostatin 1.
Tabulation of these measures will be generated using the intention to treat data sets.
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