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Flow-mediated dilation (FMD) measures endothelial function by inducing a temporary ischemia in a brachial artery and observing the amount of vasodilation following the stressor event.
The subjects received 450 mg of CF twice daily for 1 month to determine the time course of endothelial function by FMD, which measures endothelial function and is a prospectively validated surrogate marker of cardiovascular risk.
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On 4 consecutive days, we measured endothelial function by brachial artery ultrasound in all participants and by pulsewave measurements in a subgroup.
We performed a maximal exercise test (VO2max) and measured endothelial function using venous occlusion plethysmography and intra-arterial infusion of acetylcholine, sodium nitroprusside and NG-monomethyl-l-arginine.
Randomized, controlled exercise trials designed to measure endothelial function, inflammatory markers, sympathetic neural activation, and skeletal muscle metabolism and structure have further defined the pathophysiology, documented the impact of exercise training on these processes, and confirmed the benefit of this therapy.
In an observational study in Indonesia, we measured endothelial function using reactive hyperemia-peripheral arterial tonometry (RH-PAT) in 51 adults with SM, 48 patients with moderately severe falciparum malaria (MSM), and 48 controls.
Among the several non-invasive methods of measuring endothelial function, flow-mediated dilation (FMD), laser Doppler flowmetry, and digital pulse amplitude tonometry (PAT) are the most widely adopted [16 18].
There are many ways to measure endothelial function.
Venous occlusion plethysmography has been found to be a valid method of measuring endothelial function [ 12].
Finally, FMD makes it possible to repeatedly measure endothelial function in individual rats.
FMD of the brachial artery is a non-invasive technique for measuring endothelial function.
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