So the question is: Is there a way to innovate in a way that has more measured disruption?
Measured disruption sounds sensible, but it doesn't dazzle venture capitalists in the way that Kalanick's ruthless growth strategy evidently did.
In cross-linking assays designed to measure disruption of substrate DNA binding, the photoprobes behaved similarly to a reference DKA inhibitor.
The effect of shift work, and circadian rhythm disruption, on reproductive outcomes is poorly understood, although advances have been made in the development of metrics for measuring disruption of circadian rhythm in working populations.
Figure 1: Scatter plots showing measures of disruption versus the NINO3.4 SST anomaly.
We define direct measures of disruption to precipitation over the entire region of interest (that is, 140° E–25°S 15°25°S–15° N).
We will use two different measures of disruption: the spatial correlation coefficient (R); and the root-mean-squared difference (D), between seasonal (December January Februrary) and long-term (multi-decadal) average rainfall patterns.
The library was screened through a previously reported high-throughput STAT5B FP assay which measures the disruption of phosphopeptide STAT5B SH2 domain interactions.
To assay locomotion defects directly, we first assayed daily motor activity levels in individual animals using the Drosophila Activity Monitoring (DAM) system, which measures movement disruption of an infrared beam (Chiu et al., 2010).
This contrasts with a previous study that used a proxy measure of disruption based on rainfall amount at a single location14.
