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Baseline patient characteristics for demographic, disease measures, disease activity and health status are shown in Table 1.
Summary scores from the instrument show strong validity versus more complex quality of life questionnaires, generic utility measures, disease activity scores and global physician assessment.
Except for RA, similar approaches to establish core sets of measures, disease activity measures, and response criteria for RCTs have been made for several other rheumatic diseases, notably psoriatic arthritis and ankylosing spondylitis (Table 2) [ 20- 23].
The Bath ankylosing spondylitis disease activity index (BASDAI) score measures disease activity based on six questions on fatigue, spinal pain, joint pain/swelling, areas of localised tenderness and morning stiffness.
This validated composite score measures disease activity (range 0.9-9) and includes 28 swollen and tender joint counts, patients' judgment of global disease activity, and C reactive protein level.
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In ANCA associated vasculitis (AAV), clinical checklists such as the BVAS are used to measure disease activity and the VDI to measure disease and treatment related damage.
Late gadolinium enhancement can be measured semi-quantitatively using contour tracing, and more specifically, T2 mapping can be performed to measure disease activity (edema) which can be used in therapy monitoring (Yang et al., 2014).
While there were similarities between studies, particularly in the selection of primary outcomes that measure disease activity, other outcomes showed wide variability.
Several composite indices are used for measuring disease activity, response and remission.
The DAS28 CRP) is a composite score measuring disease activity, with lower scores indicating lower disease activity [ 29].
For example, a concomitant disease which raises pain levels or APRs may influence the result of measuring disease activity.
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evaluating disease activity
measures disease extent
measures disease prevalence
measures business activity
measures disease duration
measures factory activity
measures disease diagnosis
measures pathway activity
measures disease burden
measures locomotor activity
measures manufacturing activity
measures disease severity
measures refinancing activity
measures brain activity
measures disease information
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