This difference could be due to the parameters measured (developmental delay vs. cell and wing size) or to the remnants of hppy function in the alleles used in each experiment.
Further differences may arise from the fact that Hes1 is highly regulated both transcriptionally and post-transcriptionally; oscillations in Hes1 protein levels play a critical role in measuring developmental time in unsegmented paraxial mesoderm [21].
In this study, we have measured developmental and sex-based differences in hypothalamic kisspeptin expression and distribution in the hpg mouse model, to address questions of the programming role of the HPG axis itself on the kisspeptinergic system.
To measure developmental speed we compared stage-matched brains ex vivo and in vivo.
Both the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) were used to measure developmental outcomes.
We measure developmental variation by age, and distinguish those aged 35 and under from those aged 36 and over.
Awasthi 2000 measured developmental status using the Denver Questionnaire, and did not demonstrate an effect of deworming.
Finally, data on infant outcomes were only collected for up to 4 months, reducing the ability of the registry to measure developmental progress.
To quantify this, we measured developmental speed of animals laid as eggs over ∼70 h at 20 °C, during which time all wild-type animals reached adulthood.
Similarly, Sr concentration in eggs was not statistically related to any of the measured developmental parameters (in all cases r < 0.08, p > 0.14).
We investigated whether a hormetic effect of gossypol can be observed in H. armigera by measuring developmental parameters in response to different concentrations in the diet.
