Sentence examples for measures cell kill from inspiring English sources
This current study was designed to evaluate the capability of fDM for preclinical evaluation of dose escalation studies and to determine if these changes were correlated with outcome measures (cell kill and overall survival).
Specimens from 45 patients with previously-untreated non-small cell lung cancer (NSCLC) were tested for in vitro chemosensitivity to ten drugs utilising the DiSC assay, which measures cell kill in the total (largely non-dividing) tumour cell population.
Early changes in tumor diffusion values were found to be highly correlative with drug dose and independent biologic outcome measures (cell kill and survival).
Thus, such measures of apoptosis are not valid quantitative measures of cell kill.
To address the same issue in oesophageal cancer cells, we performed clonogenic cell survival assays to measure in vitro cell killing as a function of radiation dose.
Many of the 1,353 compounds tested have been associated only with more chronic or subtle toxicity in vivo, so only a small subset of the compounds might reasonably be expected to be positive in this measure of acute cell killing.
The radiosensitizing effect of doranidazole was determined using colony formation and propidium iodide (PI) assays to measure cell growth inhibition and the cell killing effect of human colorectal cancer cell lines exposed to high doses of γ-ray irradiation under hypoxic conditions in vitro.
The cell killing effects by melphalan were measured at 24, 48 and 72 hours after 15 μM melphalan treatment.
A large single dose of nicotinamide (1000 mg kg-1) enhanced the tumour cell killing by L-PAM as measured by tumour cell survival.
Therefore, measures of clonogenic survival match the measures of cytotoxicity with the HT-29 cells being shown more sensitive to the cell killing effects of irinotecan.
We determined ED50 values for phosphatidylserine externalization (i.e., the effective dose-induced apoptotic cell killing in ∼50% of the sample population as measured by annexin V positivity) in 16 lymphoid cell lines with known p53 mutational status.
