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CBZ treatment yielded significantly greater improvements on the three efficacy measures at week 8 through endpoint compared to placebo.
CBZ monotherapy produced significantly greater improvement on manic measures at week 2 through endpoint and CGI-S of depression at endpoint compared to placebo.
Table 2 summarises the effects of apremilast on additional efficacy measures at week 24.
Biomarker changes from baseline to week 4 were also correlated with clinical measures at week 14.
In this analysis, EQ-5D measures at week 12 and the last measure were used wherever possible.
Additional efficacy outcome measures at week 24 included improvements in the signs and symptoms of PsA, physical function, enthesitis, dactylitis and psoriasis (see online supplementary table S1).
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Post-randomization measures at weeks 28 and 52 were tested for between-week and treatment effects.
This study differentiated active drug from placebo in clinical composite outcome measures at weeks 12 and 16 but failed to reach its primary endpoint at week 14.
There were no gender differences for any baseline measures or for most of the 19 functional outcome measures at weeks 4 and 16.
Participating adolescents with significant depressive symptomatology, aged 12 to 18 years, will complete assessment measures at Weeks 0, 12 and 24 of treatment.
Different single and composite measures at weeks 0, 6, 14 and 22, and their differences over time were taken into account for the model building.
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