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Outcome measures will be tested using a mixed effects repeated measures analysis with the primary factors being Time as a repeated measure, tDCS condition (sham or active) and Diagnosis (unipolar or bipolar).
To test this, LDN amplitude × Deviant was entered into a repeated measures analysis with Group × Family history (+FH, −FH).
Stability of shine-through performance was analysed by a repeated measures analysis with 3 intra-individual (time points) and one between group factor (patients vs. controls).
Data were analysed using repeated measures analysis, with Fisher's protected least significant difference (LSD) as the post-ANOVA test.
To estimate and compare the effect of metformin on renal function, mixed-effects repeated measures analysis with random slope and intercept was performed.
Changes from baseline in DAS28-CRP and HAQ-DI were analysed using a mixed-model repeated measures analysis with a covariate for baseline DAS28-CRP.
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Body composition measurements (percent body fat, WC) from Tanita, insulin, HOMA-IR, and IL-6 (pre, week 6, and post) were analyzed by one- and two-way repeated-measures analysis with variance, and a post hoc Bonferroni test was administered.
Next, the challenge response curves of the different markers were compared by a repeated-measures analysis with challenge, visit, cohort, time, challenge*time, visit*time and challenge*time as fixed factors, baseline, baseline*challenge and baseline*time as covariates and the subjects as random factor, where the * refers to an interaction effect.
In a three-way repeated-measures analysis with time as a factor and BMI as covariate, glucose levels during the OGTT were significantly different among the three groups (P < 0.001) and were highest in Ab+ versus Ab− (P = 0.003) and lowest in control subects (P < 0.001).
The resulting network was subjected to a centrality measure analysis with the Plugin CentiScaPe1.1 [ 74].
In the primary analysis, outcomes of the two treatment conditions will be compared using repeated measures analysis (GLM), with the number of sessions as a covariate.
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