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The economic burden of obesity, MGI estimates, is 2.8% of global GDP, roughly equal to that of smoking or war.Almost all the measures analysed in the report are cost-effective, offering health-care savings and productivity gains that would outweigh their cost over the lifetime of the target population.

Correlations between all the measures analysed in the SLI family sample can be found in Electronic Supplementary Table S1.

Correlations between all the measures analysed in the dyslexia family samples can be found in Electronic Supplementary Table S2.

The outcome measures analysed in this study were the themes that emerged from the narrative analysis of PHCPs' written comments.

Descriptive statistics for the measures analysed in this sample are presented in Table 2. Intraclass correlations at both ages displayed DZ correlations that were roughly half MZ correlations, inferring predominantly additive genetic effects (Table 3).

Baseline assessments included the collection of the demographic, clinical, and physical activity measures analysed in the current paper including a complete medical history, a full physical examination, and either a symptom-limited graded upright cycle ergometry exercise test with direct measurement of oxygen uptake (CHRC) or a treadmill test using the Bruce protocol (CHRP) (GXT).

Mixed models are increasingly used for repeated-measures analyses in biology, agriculture and medicine (e.g. Laird & Ware, 1982; Piepho et al., 2003; Gueorguieva & Krystal, 2004; Howell, 2010).

Therefore, we examined all our hypotheses through repeated measures analyses of variance in SPSS 20.

Details of the repeated measures analyses of variance are reported in the following section (see Tables 2 4).

The difference amplitudes were analysed using repeated measures analyses of variance (r.m. ANOVA) in an Electrode*Group matrix.

We also compared proportions of patients "in control" during follow-up using priority-specific cutpoints in repeated measures analyses.

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