Thus, larger studies with C-peptide measurements or studies using more sophisticated methods for the measurement of insulin secretion, such as the intravenous glucose tolerance test or the hyperglycemic clamp, are needed to ultimately address this issue.
Apart from qualitative studies, all kind of study designs independent from type of data assessment, outcome measurement or study quality were included.
For each analysis performed, we excluded any children without data for either the cytokine measurements or any study variable.
Typically direct assays such as enzyme kinetics measurements or binding studies can be used to infer molecular function annotations.
In this way, labour, research costs and potential errors associated with replicating previous manual measurements, or cadaveric studies can be reduced.
However, cell population assays such as biochemical measurements or microarray studies can be misleading as large cell-to-cell variations are often observed, even in seemingly uniform populations.
Apart from propofol, no sedative drugs other than opioids were allowed during the 8 hours preceding the measurements or during the study period (Table 1).
Other investigators 12, 14, 16 have used the Brighton Collaboration criteria, 23 which do not allow for the diagnosis of narcolepsy without supporting investigations (e.g. CSF hypocretin-1 measurement or sleep studies).
Conventional approaches to classify molecular factors mediating these responses have targeted relatively few biological measurements or explored cross-sectional study designs, and therefore have restricted characterization of stress immune interactions.
Setups with paired samples are becoming increasingly relevant as experiments that use two or more measurement techniques for each patient, or study a set of tissues of each patient, are becoming more and more common.
