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Although these correlations among mutant animals or extreme chronotypes are promising, it remains unclear how well human period length is predicted from measurements in peripheral tissues in ordinary individuals, and whether these values correlate with sleep-wake timing in vivo.
Overall, gene expression measurements in peripheral tissues from ASD patients are still far from achieving diagnostic accuracy.
DXA at peripheral sites can be performed using either general purpose body DXA or smaller dedicated peripheral DXA for measurements in peripheral skeletal sites.
Therefore, VEGF measurements in peripheral blood are often performed as surrogate markers for angiogenesis (Tamura et al, 2001; Shimanuki et al, 2005).
We have not measured DNA-M in airway tissue; however, the major source of IL-13 production in the airways is inflammatory cells, and methylation measurements in peripheral blood are likely to better reflect asthma-related immune mechanisms.
High performance was attained in the visualization and classification of: (i) pain patients (proteomic measurements) in peripheral neuropathy; (ii) human organ tissues (genomic transcription factor measurements) on the basis of their embryological origin.
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Telomere length plays an important role in chromosomal stability and tumorigenesis, and its measurement in peripheral white blood cell DNA may be a predictor of the development of lung cancer.
We conclude that the period of human circadian behaviour is mostly driven by cellular clock properties in normal individuals and can be approximated by measurement in peripheral cells such as fibroblasts.
For similar reasons, the accuracy of lactate measurement in peripheral venous or capillary blood samples must be carefully considered.
Males (5 20 weeks old) were used for all experiments due to the fact that Ins2Akita female counterparts revealed inconsistent glycemic measurement in peripheral blood irrespective of the genotype of the CX3CR1 loci.
104 An initial Phase I study of olaparib in a cohort enriched for BRCA1/2 mutation carriers demonstrated evidence of in vivo anti-PARP activity (using PARP activity measurement in peripheral blood mononuclear cells and the surrogate marker of γH2AX induction, which accumulates at DSBs) and evidence of response in 40% BRCA carriers.
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