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Routine preoperative measurement of thyroid hormones and imaging of the thyroid is not currently the standard of care, and many patients may undergo surgery with undiagnosed thyroid disease, particularly in emergent cases.
Radioiodine is to a high extent accumulated in the thyroid gland and metabolically built into the thyroid hormones, and the biokinetics of radioiodine is used for measurement of thyroid function [[1]].
At both 22 and 32 WGA, ultrasonography of the fetal thyroid gland was performed for measurement of thyroid diameter and circumference.
Measurement of thyroid hormone.
Measurement of thyroid function parameters was not available for our cohort after hospital discharge.
Measurement of thyroid function in patients with persistent GTD is, therefore, important.
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Baseline characteristics, clinical history and serial blood samples for measurements of thyroid hormones were collected.
All study participants had direct measurements of thyroid radioactivity performed within 2 months after the accident.
Unfortunately, we did not have access to sufficient plasma volume to perform any other measurements of thyroid hormones, such as total T4, free T4 and T3.
Although no significant changes in biochemical and pathological measurements of thyroid function were observed in the rat after NaI exposure, significant changes in thyroid gene expression were observed even at the lowest concentration of NaI tested (0.1 mg/kg/day).
As we described in the "Materials and Methods" of our article (Ostroumova et al. 2013), availability of individual direct measurements of thyroid radioactivity served as a key criterion for inclusion into the study.
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