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In addition, meconium may be a good matrix to measure transient prenatal tobacco smoke exposures, as we detected nicotine in the meconium of infants born to women with undetectable serum cotinine concentrations and single serum cotinine measurement indicative of secondhand or active tobacco smoke exposure.
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Clinical confirmation of IAH requires bedside measurements indicative of IAP.
Anthropometric measurements indicative of lipid redistribution, such as skinfolds, hip and waist circumference, could be useful to document such manifestation.
Meconium tobacco smoke metabolite concentrations increased with the number of serum cotinine measurements indicative of secondhand or active tobacco smoke exposure (Table 3).
However, there was little difference in meconium tobacco smoke metabolite concentrations among infants born to women with one or two serum measurements indicative of SHS exposure.
Infant meconium tobacco smoke metabolite concentrations were about 2 times higher in women with three serum measurements indicative of SHS compared to women with no tobacco smoke exposure.
Data extracted included: BP measurements (number; values), ophthalmic examinations (number; documented absence/presence of retinopathy) and urinary albumin to creatinine ratio (ACR) measurements indicative of nephropathy (number; values): see Table 1 for definitions [ 9- 11].
Finally, we investigated whether the timing of the serum measurements influenced the association between the number of serum cotinine measurements indicative of secondhand or active tobacco smoke exposure and meconium NIC concentrations.
Relative to differences in meconium NIC concentrations, meconium COT and 3HC concentrations were higher among active smokers and women with three serum measurements indicative of SHS exposure compared to women with no exposure.
To identify the target population, i.e. patients in need of a specific treatment, either diagnostic codes or clinical measurements indicative of a disease or condition can be used.
However, among the larger number of women with SHS exposure, we did observe similar patterns of association between the number serum cotinine measurements indicative of SHS exposure and meconium tobacco smoke metabolite concentrations.
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