Northern blot analysis of total snRNA levels does not distinguish between snRNAs that contain the Sm core and those that do not, and the snRNA decrease is smaller than measured with immunoprecipitation experiments.
The best evidence against it, which we have described in the revised manuscript, is the validation of the protein abundance changes we measured with independent experiments.
DOI: http://dx.doi.org/10.7554/eLife.04640.023 10.7554/eLiFigure40.024 Figure 6 figure supplement 2. Changes in c-Myc level in response to perturbations in SkMel-133 cells as measured with RPPA experiments.
The sample of LFPs and MUAs recorded with different electrodes included significant responses to chromatic gratings, which we used to compare the LFP and MUA spatial resolution in macaque visual cortex with the spatial resolution measured with psychophysical experiments in humans.
The results from this analysis indicate that the chromatic/luminance ratio measured with psychophysical experiments in humans (Mullen 1985) is closer to the ratio measured with LFP than MUA activity (Fig. 10 a) and that the suppression caused by luminance gratings with low spatial frequencies is much more pronounced in human vision than in both LFP and MUA recordings (Fig. 10 b).
We demonstrate that LFPs respond robustly to pure chromatic contrast through the depth of the visual cortex and that the LFP visual spatial resolution (spatial frequency cutoff) is ∼2.5 times lower for chromatic gratings than luminance gratings, a value that approaches the ratio of achromatic/chromatic spatial resolution measured with psychophysical experiments in humans (∼3).
They respond robustly to both luminance and color patterns, they have better spatial resolution and weaker low spatial frequency suppression than spiking activity and they provide a better estimate of the spatial resolution ratio for achromatic/chromatic gratings measured with psychophysical experiments in humans.
By recording from awake behaving macaques in primary visual cortex, here we demonstrate that LFPs respond robustly to pure chromatic stimuli and exhibit ∼2.5 times lower spatial resolution for chromatic than achromatic stimulus patterns, a value that resembles the ratio of achromatic/chromatic resolution measured with psychophysical experiments in humans.
Additionally, stress relaxation experiments measured with DMA and deformation-fixation-relaxation experiments reveal a type of flowing and stress reduction of the crosslinked polymers caused by rearrangement reactions.
Abstract: Production of prompt J/psi meson pairs in proton-proton collisions at root s = 7 TeV is measured with the CMS experiment at the LHC in a data sample corresponding to an integrated luminosity of about 4.7 fb -1).
