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However, regardless of the reason why IIP correlates more strongly with m than with IC50, our results show that a parameter (kdrug) designed a priori to purely reflect intrinsic drug properties (such as affinity for its target) correlates well with the experimentally measured suppression of viral replication.
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Time-frequency windows were defined to measure suppression of occipital alpha- and rolandic mµ-rhythm (7 13 Hz), suppression and rebound of central beta-rhythm (15 22 Hz) as well as gamma-rhythm enhancement (25 95 Hz) in the inter-stimulus-interval (ISI) between S1 and S2.
The Vogel conflict test (VCT) is another animal model of anxiety that measures suppression of punished responses [ 16- 22].
We evaluated both contextual conditioning, as measured by suppressed activity in the context where training occurred, and cued conditioning as measured by suppression of activity in a new environment in which the conditioned stimulus (CS) is presented.
These agents differed, however, in the degree to which they produced nonselective behavioral effects as measured by suppression of responding in the S−/CS− condition.
We also measured prandial suppression of circulating acyl-ghrelin (a centrally-acting orexigenic hormone signalling acute nutrient intake), and circulating leptin levels (providing an assay of energy reserves).
Most Pol II GOF mutants do show Spt− phenotype as measured by suppression of lysine auxotrophy (Lys−) in the presence of lys2 -128∂ allele (see Materials and Methods), but there is only partial correlation with upstream shifting TSS defects.
The dose-response curves for angiostatin and endostatin (measured as suppression of tumor growth) go through an optimum (i.e., minimum tumor growth) and then becomes less effective at higher doses.
One way to assess occipital cortex excitability is to measure magnetic suppression of perceptual accuracy (MSPA).
Therefore, an assay designed to measure Treg suppression of activation marker expression by responder T cells in 7 to 20 h has been examined in this report.
We modelled the latter by measuring conditioned suppression of drug seeking (Vanderschuren & Everitt, 2004 ).
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