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The other feature is creation of events, based on measured parameter values.
For example, such variations may describe the effect of experimental error in measured parameter values or may arise as part of a sensitivity analysis of the model.
The parameter ranges were estimated using the reported uncertainties of the measured parameter values, where available.
Comparing the PBPK modeling results using literature and measured parameter values demonstrates the importance of obtaining accurate values for physiological parameters.
Incorporating the measured parameter values into the left and right sides of equation 5, we determined the density of E. coli below which it should be advantageous for φX174 to include S. typhimurium (the less profitable host) in the diet.
The use of measured parameter values in naïve and B20-4.1-administered B20-4.1-administered B20-4.1-administeredfferences, expressed as [(AUC0–7, naïve−AUC0–7, B20-4.1)/AUC0–7, naïve]×100%: 25% higher in intestine, 10% higher in heart and spleen, 3% higher in liver, 1% higher in lungs, 0.1% higher in blood and bone, 4% lower in kidneys, and 0.1% lower in micele.
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Another approach is to map each measured parameter value (e.g. concentration of PO4, or temperature) to a normalised index value by use of a graphical function (or lookup table) of parameter value (Cude,2001).
With this aim, the relevant water quality guidelines were used to develop functions with which each measured parameter value (e.g. concentration of PO4, or temperature) is mapped to a Health Index (HI) for that parameter, the scale of which ranges from 0 (zero) to 1 (unity), where 0 represents the worst condition possible and 1 represents a healthy, perfect state.
This means that field ecologists can use the homogeneous IDE as a relatively simple modelling tool – in terms of both measuring parameter values and doing the modelling itself.
The Bayesian inference calculates the probability of different values of the measured parameter 'given' the data.
SD values were preferred to SEM since they better reflect variabilities of the measured parameters than SEM values.
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