Á dose-response curve of inhaled APC was prepared by administering increasing concentrations of the drug to three mice and measuring lung elastance H and airway resistance RN every 10 seconds for 30 minutes.
Fig. 3 Measured lung resistance (a) and lung elastance (b) over a wide array of frequencies using an OVW technique in healthy, mild-to-moderate asthma, and severe asthma.
We measured lung function (respiratory system elastance H), arterial blood gases, surrogates of vascular leak (broncho-alveolar lavage (BAL) total protein and angiotensin-converting enzyme (ACE -activity), ACE -activitys of inflandation (BAL neutroparameterslung tissue myeloferoxinflammationactivity).
Using computed tomography region of interest analysis, they measured lung aeration and respiratory system elastance in six anaesthetised and paralysed healthy piglets at descending PEEP levels.
We measured the static lung elastance, ratio of arterial partial pressure per inspiratory fraction of oxygen (PaO2/FIO2), mean arterial pressure, cardiac output, systemic vascular resistance and inotropic score.
Once functional residual capacity was measured (see below), specific lung elastance was computed as the slope of the linear part (by visual inspection) of the stress strain curve.
To study the time course of lung edema formation we compared lung elastance measured by forced oscillations with invasive methods of lung edema detection (for example, wet dry weight ratio and histology).
Since greater lung elastance measured in infants is inversely related to ventilatory efficiency and could result in alveoli collapse, it may be particularly important to limit influenza infection and reduce the extent and duration of tachypnea in this very young age group.
Static lung elastance (Est,L) measured at BASELINE (positive end-expiratory pressure = 5 cmH2O) and at END. Animals were randomly assigned to hypovolemia (HYPO), normovolemia (NORMO) or hypervolemia (HYPER) with recruitment maneuver (RM-CPAP) or not (NR).
