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The GEE model accounts for our longitudinally measured endpoint of driving status and our correlated data that was due to repeated measures (Hanley et al. 2003).
The measured endpoint of the experimental data is not the lethal dose concentration (LD50), but more subtoxic events such as inflammation, oxidative stress response, or gene expression profiling over different time scales were assessed, which make a sound comparison of the studies impossible.
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One should be reminded that in this MG test we are limited in terms of measured endpoints to survival and reproduction, hence a refined understanding is limited.
Induction of CYP1A expression is widely used as a biomarker of exposure to contaminants including PAHs and HAHs and is a readily measured endpoint in studies of the mechanisms of AHR signaling [ 65].
The assessment of the relevance of the data should describe "the extent to which a test is appropriate for a particular hazard or risk assessment" [9], e.g., answer questions like: Is the measured endpoint a valid indicator of environmental risk?
Three products induced responses in one or more of the measured endpoints and toxicity profiles varied markedly in intensity across products.
Their analyses addressed selective reporting of subgroup results in the context of randomized trials, a topic further discussed below, and reporting a selected subset of multiple measured endpoints.
Sun et al. also found that subjects with diabetes were marginally less likely to reach either of their measured endpoints than those without diabetes.
There was a little overall effect of salinity on measured endpoints.
Results: No significant associations were found between prenatal MeHg exposure and any of the repeatedly measured endpoints.
Some of these characteristics are used relatively directly to measure endpoints related to goals of environmental management (i.e., ecosystem services), whereas others are combined together to infer pollution levels.
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CEO of Professional Science Editing for Scientists @ prosciediting.com